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KMID : 1149220150230010121
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Korean Journal of Oriental Medical Prescription
2015 Volume.23 No. 1 p.121 ~ p.131
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Study of Membrane Potential Analysis According to Applying Doksam-tang to a Human Heart Failure Model
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Jeong Dae-Yeong
Lee Boo-Kyun
Hong Jin-Woo
An Won-Gun
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Abstract
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Objectives : This study was conducted to investigate the membrane potential to apply Doksam-tang to a human heart failure model.
Methods : The human heart model was built by Luo et al. CellML model, Priebe et al. CellML model, and a human heart mesh file. Doksam-tang gives channel the half maximal inhibitory concentration(IC50), half maximal effective concentration(EC50) values and compounds concentrations. These data load into the laptop with Ubuntu OS, and build the library with the data.
Results : While results of the study with the heart failure model shows abnormal membrane potential from the normal heart model, the study with applying Doksam-tang to heart failure model shows restoring membrane potential that is similar to normal heart model.
Conclusions : These results of the testings suggest that a conception of novel technique to investigate the effects of Korean herbal medicine.
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KEYWORD
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heart failure, computer modelling, Doksam-tang, physiome, korean medicine, systems biology
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